Fradditive™ Stability Screen: Fragment-Salt contains a range of fragments from Fradditive(TM) Screens 1 and 2 in a sparse matrix format of salts and compounds. The 96 solutions are unique and not available from any other vendor
Aqueous solutions are shipped in deep well blocks as a sparse matrix of 24 salts and 32 fragments. Individual reagents are available for purchase. Primary application of this product is for protein stabilization assays by thermal shift and elimination of non-specific aggregates. The screen may also be used during crystal optimization.
Fradditive™ Stability Screen: Fragment-Salt
- 0.5 ml each of 96 unique mixtures in aqueous solution
- Compound concentration is 10mM
- 24 unique salts
- 32 unique fragments
- Pre-plated in deep well block format
- Mixtures were generated through sparse matrix
- Formatting may be customized to meet your need
- Individual solutions are available for purchase separately
- Protein solubilization: Mixtures may improve protein solubility and may be included during lysis or purification.
- Protein stabilization: Compounds may be in conjunction with a thermal shift assay to identify conditions where the protein is more stable in solution for both purification and crystallization.
- Crystal optimization: The mixtures could be used to improve diffraction or crystal size and is applicable to all protein classes.