Definition of Fradditive™: (1) fragments of a ligand or macromolecule found bound to proteins in nature; (2) very small chemical fragments of known drugs or natural products. 

 

Why Fradditives™?

 

• Ligands stabilize proteins in solution improving stability and crystallizability

• Serendipitous contaminants, buffer or crystallization components have been critical for crystallizability 

• Ligands have not been routinely incorporated into commercial screens

• 20 years of fragment-based lead discovery data shows that fragments find binding sites on proteins

• Not all fragments alter protein activity but are relevant to protein stability

• We introduce a series of Fradditive™ screens to expand the diversity and productivity of ligands in protein purification and crystallization

 

Fradditive™ Product Line

 

• Low molecular weight (< 150) and soluble to 10mM in aqueous solution to improve their probability of binding to your target

• 96 conditions pre-formulated and ready for use

• 0.5ml of each solution in deep well blocks

• Fradditve™ reagents may be purchased in bulk to ensure reproducibility in large-scale purification and crystallization processes

• Exclusive to Zenobia

 

 

 

 

 

*Patent pending