Fragment Library Products for Drug Discovery

Zenobia has a full 960 compound fragment library collection sufficient for screening even the most difficult target. The compounds cover a range of shapes, sizes and properties and our library is the most core diverse on the market. The collection is designed to be screened together but has been divided into four individual libraries with different properties to meet the unique needs of your program.  We now offer ZEN-CORE 288™ well plate designed to sample all four of our libraries.

 

We have a product to meet your scientific goals and budget: Purchase the full collection, individual libraries or our new Rapid-Screen plate to get started screening!

 

Libraries may be purchased through PO or through our online store.

 

ZEN-CORE 288™

ZEN-CORE-288™ is the newest addition to Zenobia Fragment's consumable line of products. It is a highly efficient CORE screen that samples Zenobia’s 968 compound collection. ZEN-CORE 288™ is designed to yield quality leads and provide early information about the drugability of your target. ZEN-CORE 288™ is the first off-the-shelf consumable fragment library.  It is pre-formatted in a 384 well plate format and ready for immediate screening. Each of the 288 fragments is accurately pre-spotted with 1ul of a 200mM stock ZEN-CORE 288™ solution. The first and last two columns of the 384 well plate are left blank to provide ample room for your internal controls. Approximately 30 micrograms of compound are included which is suitable to conduct at least one fragment screen by most methodologies. Typical hit rate for this screen is 3-10% for an average target. All fragments are soluble to 200mM in 100% DMSO and 1mM in aqueous solution. Additional compound may be purchased separately. Contact us for a quote or purchase through our online store.

 

  • 288 compounds

  • Supplied in a single 1 ul/well pre-spotted 384 well plate

  • Approximately 30 micrograms of each compound is included in the kit

  • 1ul of 200mM stock solution per well

  • Provides early information regarding a target’s drugability

 

 

ZEN-LIBRARY 1™

ZEN-LIBRARY 1™ is composed of 352 compounds hand selected with a focus on cores found in drugs.  All compounds are composed of at least one ring with the majority being aromatic (70%). ZEN-LIBRARY 1™ has a higher functional diversity than other Zenobia Libraries permitting efficient sampling of drug-like chemical space. ZEN-LIBRARY 1™ has been used world-wide for over 10 years yielding hits for over 100 therapeutic targets, including protein-protein interactions. Hits have been detected by all popular methods including X-ray, NMR, thermal shift, SPR, and biochemical assay. All fragments are soluble to 200mM in 100% DMSO and 1mM in aqueous solution.  Fragments are plated pre-grouped into shape diverse mixtures for efficient crystallographic screening.  Call for a quote or order from our online store.

 

  • Cores derived from those common in drugs and found bound to proteins (PDB)

  • Cores are primarily single ring aromatic (70%) with a minimal number of non-aromatic compounds (6%)

  • All compounds are composed of at least one ring (aliphatic or aromatic or both)

  • Lower core diversity than other libraries but higher functional diversity

  • Used world-wide for over 10 years with hits for multiple target classes including protein-protein interactions

 

 

 

ZEN-OPTI™

ZEN-OPTI™ is a fragment library of 160 unique compounds having intermediate complexity. It combines the design principles and characteristics of both ZEN-LIBRARY 1™ and ZEN-LIBRARY 2™ in a stand-alone library. The library is composed of additional drug-like cores combined with cores with higher sp3 character. The ZEN-OPTI™ screen has been used world-wide for over 5 years yielding hits by all popular methods including X-ray, NMR, thermal shift, SPR, and biochemical assay and is a great addition to Zenobia’s fragment library collection. All fragments are soluble to 200mM in 100% DMSO and 1mM in aqueous solution.  Call or email for a quotation or order from our online store.

 

  • 164 compounds

  • Supplied in two 96-well plates or one 384-well plate

  • Drug-like character with added sp3 character versus ZEN-LIBRARY 1™

  • Combines the optimum design principles and characteristics from ZEN-LIBRARY 1™ and ZEN-LIBRARY 2™

  • Hits for multiple target classes including protein-protein interaction

     

 

 

 

 

ZEN-LIBRARY 2™

ZEN-LIBRARY 2™ is composed of 288 compounds hand-selected to have high Murcko core diversity. ZEN-LIBRARY 2™ contains more complex cores than ZEN-LIBRARY 1™, ZEN-FLEX™, and ZEN-OPTI™ including fused ring aromatics, unique heterocycles and higher sp3 character. ZEN-LIBRARY 2™ has been used world-wide for over 5 years yielding hits by all popular methods including X-ray, NMR, thermal shift, SPR, and biochemical assay.  All fragments are soluble to 200mM in 100% DMSO and 1mM in aqueous solution.  All Zenobia libraries maintain the highest of standards with both functionality and efficiency.  These principles ensure that our products maintain scientific integrity and add value to the research community.  Call or email today for a quote or visit our online store.

 

  • Contains 288 compounds

  • Composed of more unusual cores 

  • sp3 character slightly higher than ZEN-OPTI™

  • Library is composed of approximately equal single and double ring aromatics (~40% each)

 

 

 

 

ZEN-FLEX™

ZEN-FLEX™ is the most unique commercially available fragment screen on the market.  It contains 167 hand-selected compounds primarily with high aliphatic character and flexibility to either adapt to 3D surfaces of proteins, bind to smaller sites, identify secondary sites, or navigate through narrow solvent channels. It is an ideal fragment screen for challenging targets.  ZEN-FLEX™ is the lowest molecular weight and most polar library in the Zenobia collection making it an ideal screen to obtain additional structure/function information to optimize hits identified from ZEN-LIBRARY 1™, ZEN-LIBRARY 2™, and ZEN-OPTI™.  It has been successfully used world-wide for over 5 years consistently yielding hits by all popular screening methods including X-ray, NMR, thermal shift, SPR, and biochemical assay. All fragments are soluble to 200mM in 100% DMSO and 1mM in aqueous solution and supplied in either 96 or 384 well formats. 

 

  • High aliphatic character and most of the compounds (70%) have no aromatic ring

  • Lowest molecular weight library

  • Most polar of the four libraries

  • Designed to find secondary binding sites that could be used in optimization of other fragments through linking or merging, or a starting point for challenging targets

 

 

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