PART 1: What is Chemical Diversity? This is the first in a three-part series discussing chemical diversity. In Part 1, we introduce the concept of diversity in the context of fragment screening libraries. How does one understand Chemical Diversity? Merriam-Webster dictionary defines diversity as: “an instance of being composed of differing elements or qualities". In the context of screening libraries, we refer to chemical diversity as the diversity of the chemical composition

As fragment screening continues to grow in popularity and establish itself as an integral part of discovery research, the emergence of more and more compounds added to fragment library collections seems to grow exponentially. What once was an efficient means of effectively screening a target to provide information about its drugability or identify the unique building blocks of a clinical candidate, has now become diluted in a pool of tens or hundreds of thousands of compounds